Most Heartbreaking Moments in Anime?

Gosh so many but most recent was......was sasha death...but i didn't cry but i was a bit piss since i told myself not to read the manga but watch the anime instead so i see it all for the first time. But, I felt something for her death. But the first time i just broke down and cried really hard and couldn't control it was AIR.When her little girl got up and walked to her mom.....every step was her life force leaving and once she walked to her mom she died in her arms. Also it hit me harder considering that the japan voice actress that played misuzu died of ovarian cancer not long after this anime made it a little worse for me and many others when they heard the voice actor had cancer and died after this anime..........now that was fucked up the voice actor and her character both died from an illness.ITS JUST REALLY FUCKED UP...I felt so fucking bad that the voice actor didn't survive like her character didn't...the fact that she portray and then while struggling herself in battle with cancer while the character she once did battle for her life in the anime but eventually died to it...and having her die from hers...hit me hard... https://www.youtube.com/watch?v=0m_26OkleSY she also voice rose... https://www.youtube.com/watch?v=gaH8KmuAn5Y