There are a lot of great ones out there, but my personal favorite is Chobits. The main character is so relatable. See how we look alike? and Chi is so cute and adorable! It just makes you feel good watching it ^_^
My favorite is the Disappearance of Nagato Yuki-chan because I can really relate to Yuki in a lot of ways. Yuki is a really shy bookish girl that is very cute, adorable, and sweet.
almost forgot sango but miroku kind of deserved it