Death of Nagisa (you know which series), and i think i posted this exact thing in another post, and as Mercule says, the death of Ushio, god *expletive expletive* saddest thing I ever saw in an anime (almost made me stop watching anime altogether) *hides behind cloak whilst shedding the manlyist tear you ever saw*
Most recent would have to be the ending of Guilty Crown the last scene when he puts on the earphones and the music starts playing. Yeah brought a tear.to my eye lol
Yeah that was pretty sad, but i couldnt get over how bad the ending was to really care. I posted in that other thread i thought it was the worst ending to a series in recent memory
When ushio and tomoya finally bond in Clannad AS and then a few episodes later during her Death
Another would be Micheal's death in Macross F. It just hit all the right notes with the sacrifice, klans desperation to reach him, and Sharyl's song.