Nothing groundbreaking, but it is a bold choice. By the way, the footwork. Accurate! XD
As people have said Aku no Hana is pretty unique being entirely rotoscoped, theres also Ping Pong and Tatami Galaxy. Also Space Dandy sort of counts I guess since it often changes animation styles and directors even sometimes for an entire episode.
Kill la Kill
Not sure if it's a good example, but the style of youjo senki. I'm talking about the lolis and their uncanny as hell faces. Like wtf is this. xD
At first I thought that Tanja is some sort of frog-human-hybrid and that the plot is all about her DEFORMATION