Best Anime Ever ?

As for best VG-based ones: Hoshi no Kirby F-Zero: Falcon Densetsu Sonic X (Japanese version)? Virtua Fighter Pokémon (some seasons)

I would say Baccano! It's pretty much what would happen if Quentin Tarantino made an anime. Awesome characters, a story that is well put together and easy to understand despite the timeline constantly jumping around, and great music. Also, there isn't a main protagonist in the series which I found interesting.

I really like Akatsuki no Yona because I'm a big fan of its character development and humour. It's quite light watching though, so only watch it if you like shoujo.