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Set in a post-apocalyptic city called Paradigm City, where all of its inhabitants appear to have lost all their memories after a tragedy known as “The Event”. The city is governed by the Paradigm Corporation, and class inequity is evident.

Near the end of the 20th century, a nuclear flame engulfed most of the Earth's surface, reducing most of the world into a vast desert wasteland. The survivors of mankind banded together in tribes in order to fight over the few supply of uncontaminated food and water still left in the world, with the strong often preying on the weak.

Known for its Space Western theme, Trigun is about a man named "Vash the Stampede" and the two Bernardelli Insurance Society employees who follow him around in order to minimize the damages inevitably caused by his appearance. Most of the damage attributed to Vash is actually caused by bounty hunters in pursuit of the "60,000,000,000$$" (sixty billion "double dollars") bounty on Vash's head for the destruction of the city of July.

Following a cataclysmic nuclear war, the world teeters on the brink of complete destruction. Civilization is polarized into a degenerate society where opposing packs of marauding scavengers prey on helpless, <br/>homeless nomads.

Saotome Ranma, a teenage martial artist, and his father Genma travel to the 'cursed training ground' of Jusenkyo in China. There, despite the warnings of the Chinese guard, they fall into the cursed springs.