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Mutated homo sapiens that have a dangerous telekinetic power is being captured and isolated in laboratories by the government. One of the sixth-sense-possessing humanoids escapes loses her memories and winds up living with a boy from her past.

The Diclonius (two-horned human) are mutants created by humans. It has a special ability that can be described as a sixth sense.

Within Thailand lies the city of Roanapur, a safe haven for all types of criminals and where corruption thrives to its very roots. Ran by big crime syndicates like the Yakuza or the Russian and Italian mafias, Roanapur is the center for illegal and criminal activities, and is the base of operations for the notorious group called Black Lagoon.

Okajima Rokuro - now known almost exclusively as 'Rock' - was once a typical, put-upon Japanese businessman. Then, on a routine business trip, he was kidnapped and ransomed by the Lagoon Company: a band of mercenary pirates operating out of the crime-riddled city of Roanapur.

Hellsing, a secret organization within the British government, has long been battling supernatural threats to keep people safe from creatures of the night. They have a secret weapon in the form of an incredibly powerful vampire Alucard.

Nonomiya Yuuta, a ski Jumper aiming for Olympic gold, bursts onto the stage with his exceptional skills. However, his biggest problem is that he is not really a "HE".

Alucard is not just any immortal, but probably one of the oldest and strongest beings known to exist. This vampire, however, is duty bound to the Hellsing family, who acts as the dogs of England's queen, protecting the country from the most dangerous parts of the underground, namely other vampires.