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Mutated homo sapiens that have a dangerous telekinetic power is being captured and isolated in laboratories by the government. One of the sixth-sense-possessing humanoids escapes loses her memories and winds up living with a boy from her past.

Failure Human Tsukune is unexpectedly put into a school for monsters, where he meets the cute vampire Moka. He later meets succubus, Kurumu, a young witch genius, Yukari, an ice girl, Mizore, and Ruby a second older Witch Adept, Ruby.

Minato Sahashi is extremely intelligent, yet due to his inability to cope under pressure has failed the college entrance exam twice. As a result he has been branded an idiot and loser by many.

After living with his father and learning martial arts in the mountains for 17 long years, Yoichi Karasuma is sent to a hectic city-life under his father’s orders. He is received by the Ikaruga household -- also a martial arts family -- which practices the Ukiha Divine Wind Style Swordplay.

There once was a man named Gold Rodger, a pirate, and he was given the glorious title: ‘King of the Pirates’ for possessing the legendary treasure, One Piece. He had fame, fortune, and power, until one day, he caught and brought to the execution tower to be executed.

The Diclonius (two-horned human) are mutants created by humans. It has a special ability that can be described as a sixth sense.