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Naruto: Shippuuden is the continuation of the original animated TV series Naruto.The story revolves around an older and slightly more matured Uzumaki Naruto and his quest to save his friend Uchiha Sasuke from the grips of the snake-like Shinobi, Orochimaru.

Before Naruto's birth, a great demon fox attacked the Hidden Leaf Village, causing rampant death and destruction. It was powerful and unbeatable, a real plight on the village.

The suspense horror/dark fantasy story is set in Tokyo, which is haunted by mysterious "ghouls" who are devouring humans. People are gripped by the fear of these ghouls whose identities are masked in mystery.

Strange murders are happening in Tokyo. Due to liquid evidence at the scene, the police conclude the attacks are the results of "eater" type ghouls.

Mutated homo sapiens that have a dangerous telekinetic power is being captured and isolated in laboratories by the government. One of the sixth-sense-possessing humanoids escapes loses her memories and winds up living with a boy from her past.

The Diclonius (two-horned human) are mutants created by humans. It has a special ability that can be described as a sixth sense.