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Mutated homo sapiens that have a dangerous telekinetic power is being captured and isolated in laboratories by the government. One of the sixth-sense-possessing humanoids escapes loses her memories and winds up living with a boy from her past.

The Diclonius (two-horned human) are mutants created by humans. It has a special ability that can be described as a sixth sense.

Thought your life was bad? Sometimes, death is worse.

Thought your life was bad? Sometimes, death is worse.

Under the care of her adoptive family, Saya Otonashi has been living the life of an anemic amnesiac, but otherwise ordinary schoolgirl. However, her happy life is shattered when she is attacked by a Chiropteran, learning that she is the only one who can defeat them.

* A new original animation based on the Blood franchise and featuring popular mangaka collaboration Clamp as original character designers. Ukishima Shrine is located in an old, picturesque lakeside town.

On June 1983, Keiichi Maebara moves with his family to Hinamizawa, a peaceful rural village. He quickly befriends his new schoolmates Rena Ryugu, Mion Sonozaki, Satoko Hojo, and Rika Furude, usually spending their leisure time playing board games.

The story picks up after what happened in season one. Things that are left unexplained in the first season get explained in the new season in three separate arcs.

The endless cycle of murders has been broken and Rika is finally able to settle down for a normal life with her friends. However, she is involved in a traffic accident and wakes up in a world where everything is different.