I have to agree with Konosoba. Aqua, Megumin, and Lalatina have the shittiest, funniest personalities!
Sakamoto Desu Ga got me laughing so much!
Obviously it has to be Gintama. It's too funny.
asobi asobase is hitting all the right notes atm xD
Out of all the ones I've seen, this moment right here is the pinnacle for me for some reason XD
Prison School but GTO is a close second.
Gotta go with Konosuba like so many others here. I really didn't expect it to make me laugh so much, but it's just so good at what it does
Probably One Punch Man. Normally I don't care much for Japanese humor, but at least that one translated well into English from Japanese...