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Gurren Lagann takes place in a fictional future where Earth is ruled by the Spiral King, Lordgenome, who forces mankind to live in isolated subterranean villages. These villages have no contact with the surface world or other villages, and are under constant threat of earthquakes.

In the decade since the world became aware of the existence of magic, the world has undergone massive upheaval. However, a boy named Touta lives in seclusion in a rural town far removed from these changes.

After losing their mother, Alphonse and Edward Elric attempt to bring her back using the forbidden science of human alchemy. However, alchemy operates on the theory of equivalent trade, and breaking the human alchemy infooo carries a heavy price.

Shibusen, standing for Death Weapon Meister Academy (DWMA) the technical school for Reaper Armsmasters that operates from the deepest recesses of all the corners of the world, in order to prevent the second coming of the so-called Demon God who is feared upon bringing destruction of all humankind and envelop the world with nothing but madness and darkness. The reaper built this agency for weapons and for those who will be trained to wield them.