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Fullmetal Alchemist: Brotherhood, commonly referred to as FMAB is the second adaptation of the hit manga series Fullmetal Alchemist by Hiromu Arakawa. In 2003, shortly after the manga began its run, the first adaptation titled Fullmetal Alchemist was made.

While on the surface Yuu Otosaka appears to be just another charming and intelligent teenager, he has a secret—he has the ability to slip into people's minds and fully control their body for five seconds at a time. Yuu has been using this skill for years to gain the highest grades, which allowed him to enter a prestigious high school.

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After losing their mother, Alphonse and Edward Elric attempt to bring her back using the forbidden science of human alchemy. However, alchemy operates on the theory of equivalent trade, and breaking the human alchemy taboo carries a heavy price.

A fugitive alchemist with mysterious abilities leads the Elric brothers to a distant valley of slums inhabited by the Milos, a proud people struggling against bureaucratic exploitation. Ed and Al quickly find themselves in the middle of a rising rebellion, as the exiled Milos lash out against their oppressors.

The brothers Elric will consider the answers that are left once the Philosopher's Stone has guided their saga to and end. True sacrifice, the deep love of family, the cruel truths of life and death.