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The story takes place in Seikyou Private School. A facility that consists of multiple buildings that connect together to accommodate both junior and senior high school students.

The story follows Issei Hyodo, a dim-witted, lecherous second-year high school student who is killed by a girl on his first date ever. Issei is reincarnated as a devil, and from that day forward, he serves as an underling of Riasu, a high-level devil who is also the prettiest girl on Issei's campus.

Set in a slightly futuristic world, Earth has been invaded and is at war with aliens from another dimension called the Nova. In order to counter them, Pandoras and Limiters, genetically modified girls with super fighting skills and their male partners who use special "freezing" powers to limit their opponent's mobility, are made to fight against the Nova.