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Mutated homo sapiens that have a dangerous telekinetic power is being captured and isolated in laboratories by the government. One of the sixth-sense-possessing humanoids escapes loses her memories and winds up living with a boy from her past.

This show is set at Honn0ji Academy, a fictional high school in post-apocalyptic Japan that is dominated by its fearsome student council, led by Satsuki Kiryuin. The council members wear special uniforms called Goku Uniforms that grant them superhuman abilities, which they use to oppress the rest of the school's students and staff.