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Failure Human Tsukune is unexpectedly put into a school for monsters, where he meets the cute vampire Moka. He later meets succubus, Kurumu, a young witch genius, Yukari, an ice girl, Mizore, and Ruby a second older Witch Adept, Ruby.

Mutated homo sapiens that have a dangerous telekinetic power is being captured and isolated in laboratories by the government. One of the sixth-sense-possessing humanoids escapes loses her memories and winds up living with a boy from her past.