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After the unsustainable growth of the human population on Earth, the United Nations has opted to colonize Mars. During this expedition, the humans discovered two alien technologies: The Bacillus virus and the Crusnik nanomachines.

Known for its Space Western theme, Trigun is about a man named "Vash the Stampede" and the two Bernardelli Insurance Society employees who follow him around in order to minimize the damages inevitably caused by his appearance. Most of the damage attributed to Vash is actually caused by bounty hunters in pursuit of the "60,000,000,000$$" (sixty billion "double dollars") bounty on Vash's head for the destruction of the city of July.

Trigun: Badlands Rumble is a 2010 film by Madhouse. It is based on the Trigun manga, written by Yasuhiro Nightow.

In a strange time there is a war that never stops - inn world where flesh-eating monsters are roaming the streets, only one organization has the means to save the world from the Chiropterans and total destruction: Red Shield. These Chiropterans can change their form and disguise as human beings, but they are not.