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Gurren Lagann takes place in a fictional future where Earth is ruled by the Spiral King, Lordgenome, who forces mankind to live in isolated subterranean villages. These villages have no contact with the surface world or other villages, and are under constant threat of earthquakes.

Opening Kensuke Nimura is your average high-school student—except he can see spirits. This ability generally hinders him more than it helps him, especially in trying to get a girlfriend.

As a punishment for punching a famous Calligrapher, young handsome Calligrapher Handa Seishu is exiled to a small island. As someone who has never lived outside of a city, Handa has to adapt to his new wacky neighbors, like people traveling on a tractor, unwanted visitors who never use the front door, annoying kids using his home as a playground, etc.

When a great demon fox attacked Hidden Leaf Village, a powerful man known as the 4th Hokage had sealed the demon inside a newborn named Naruto, who then grew up detested by his fellow Leaf villagers. As a child, Naruto is isolated from the Konoha community, who regards him as if he was the Nine-Tails.