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Being just a normal student without a special talent, Makoto Naegi wins a lottery to attend the prestigious Hope's Peak Academy where only the top prodigies attend. However, instead of this being the beginning of a wonderful high school life, it's a ticket to despair, because the only way to graduate from Hope's Peak Academy is to kill one of your fellow students or be one of their victims.

The story of JoJo's Bizarre Adventure centers around the misadventures of the Joestars, a powerful family with English roots; most of its members attract the most particular trials and tribulations when confronting their enemies. Each member of the bloodline has a star shaped birthmark above their left shoulder blade – Dio and his descendants have this distinguishable mark also, as a result from the 'theft' of Jonathan's body and inheriting the Joestar genes as well.