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After losing their mother, Alphonse and Edward Elric attempt to bring her back using the forbidden science of human alchemy. However, alchemy operates on the theory of equivalent trade, and breaking the human alchemy taboo carries a heavy price.

When a great demon fox attacked Hidden Leaf Village, a powerful man known as the 4th Hokage had sealed the demon inside a newborn named Naruto, who then grew up detested by his fellow Leaf villagers. As a child, Naruto is isolated from the Konoha community, who regards him as if he was the Nine-Tails.