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On August 10th of the year 2010 the Holy Empire of Britannia began a campaign of conquest, its sights set on Japan. Operations were completed in one month thanks to Britannia's deployment of new mobile humanoid armor vehicles dubbed Knightmare Frames.

A year has passed since "The Black Rebellion" and the remaining Black Knights have vanished into the shadows, their leader and figurehead, Zero, executed by the Britannian Empire. Area 11 is once more squirming under the Emperor's oppressive heel as the Britannian armies concentrate their attacks on the European front.

Bulma is a girl in search of the mystical dragonballs that when brought together grant any wish. In her search she bumps into the owner of one of these balls, a strange boy named Goku.

The series follows Dr. Kenzo Tenma as he pursues a young psychopath/sociopath named Johan, whose life Tenma had once saved.