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The story of JoJo's Bizarre Adventure centers around the misadventures of the Joestars, a powerful family with English roots; most of its members attract the most particular trials and tribulations when confronting their enemies. Each member of the bloodline has a star shaped birthmark above their left shoulder blade – Dio and his descendants have this distinguishable mark also, as a result from the 'theft' of Jonathan's body and inheriting the Joestar genes as well.

Gatts, an incredibly powerful warrior, is a lone swordsman in a medieval-type fantasy world. He loses in a battle with a mysterious swordsman named Griffith, who holds a pendant called the Eye of God.