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Gurren Lagann takes place in a fictional future where Earth is ruled by the Spiral King, Lordgenome, who forces mankind to live in isolated subterranean villages. These villages have no contact with the surface world or other villages, and are under constant threat of earthquakes.

Follows the life of an average hero who manages to win all battles with only one punch. This ability seems to frustrate him as he no longer feels the thrill and adrenaline of fighting a tough battle, which leads to him questioning his past desire of being strong.

Ikebukuro, Tokyo. Mikado Ryugamine is a young man who yearns for the city like no other.

As a punishment for punching a famous Calligrapher, young handsome Calligrapher Handa Seishu is exiled to a small island. As someone who has never lived outside of a city, Handa has to adapt to his new wacky neighbors, like people traveling on a tractor, unwanted visitors who never use the front door, annoying kids using his home as a playground, etc.

It’s a new school year and Ryuuji Takasu discovers not only is he in the same class as his best friend, Yusaku Kitamura, but also Minori Kukshieda whom he's had an undisclosed crush on for quite some time. Ryuuji, the main character, runs into Aisaka Taiga who happens to live next door.

During the late 1930s in Chicago, the transcontinental train, Flying Pussyfoot, is starting its legendary journey that will leave a trail of blood all over the country. At the same time in New York, the ambitious scientist Szilard and his unwilling aide Ennis, are looking for missing bottles of the immortality elixir.

Makunouchi Ippo is an ordinary high school student in Japan. Since he spends most of his time away from school helping his mother run the family business, he doesn't get to enjoy his younger years like most teenagers.

Naota is a normal Japanese 6th grade boy, cynical about life and just wanting to be left alone. But his older brother leaves for America to play baseball, leaving his homeless 17 year old girlfriend Mamimi behind.

Moritaka Mashiro and Akito Takagi are pretty much foils of each other. Mashiro, an average 9th grade student but talented artist, and Takagi, an overall advanced 9th grader and aspiring writer.

The life of Satou Kazuma, a hikikomori who likes games, all too soon came to an end because of a traffic accident..